2016 TMS Update at CPCH

As you may recall, in 2016 CPCH has been treating patients with Major Depressive Disorder with TMS (transcranial magnetic stimulation). As part of the Gil Internship, we were fortunate to have Swapnil Patel, a UNC undergraduate Psychology major, to help us analyze our TMS outcomes data for 13 patients who completed the TMS protocol at CPCH. We wanted to share these exciting results:

 

Patient Demographics (what kind of patients completed the TMS protocol)

Patient Demographics

Measurement Tool – PHQ-9

THE PATIENT HEALTH QUESTIONNAIRE (PHQ-9) OVERVIEW

The PHQ-9 is a multipurpose instrument for screening, diagnosing, monitoring and measuring the severity of depression:
• The PHQ-9 incorporates DSM-IV depression diagnostic criteria with other leading major depressive symptoms into a brief self-report tool.
• The tool rates the frequency of the symptoms, which factors into the scoring severity index.
• Question 9 on the PHQ-9 screens for the presence and duration of suicide ideation.
• A follow up, non-scored question on the PHQ-9 screens and assigns weight to the degree to which depressive problems have affected the patient’s level of function.

Response = 50% reduction of symptoms on the PHQ-9
Remission = PHQ-9 score < 5

OVERALL RESULTS

Figure 1a. Average patient PHQ-9 scores at baseline and following TMS treatment (n=13)

PHQ9 Scores

Figure 1b. Average patient response and remission rates through 20 TMS sessions (n=13)

Percentage of Patients

RESULTS FROM PATIENTS WITH SEVERE DEPRESSION

Figure 2a. Patient PHQ-9 scores after 10 and 20 TMS sessions with baseline PHQ-9 ≥ 20 (n=5)

PHQ-9 Scores

RESULTS FROM PATIENTS WITH MODERATE DEPRESSION

Figure 3a. Patient PHQ-9 scores after 10 and 20 TMS sessions with baseline PHQ-9 11-19 (n=7)

PHQ-9 Scores1

RESULTS FROM PATIENTS WITH MILD DEPRESSION

Figure 4a. Patient PHQ-9 scores after 10 and 20 TMS sessions with baseline PHQ-9 ≤ 10 (n=1)

PHQ-9 Scores after 10 sessions

So what does it all mean? Here are the take-away points:

Some additional notes on the TMS experience:

If you would like to know if you are a candidate for dTMS please contact our offices at 919-636-5240.

Live Mentally Healthy,
Dr. Jennie Byrne

Author
Dr. Jennie Byrne, M.D., PhD. With over 15 years of medical expertise, Jennie Byrne, MD, PhD, is a board-certified psychiatrist with experience treating mental health conditions in adults, including dementia, attention-deficit hyperactivity disorder, anxiety, and depression. After practicing in New York City for 12 years, Dr. Byrne relocated to North Carolina in 2008; she currently cares for patients in Chapel Hill, North Carolina, at Cognitive Psychiatry of Chapel Hill. Dr. Byrne earned her bachelor’s degree at the University of Pennsylvania in Philadelphia. She then received her doctorate from New York University Department of Neurophysiology. She also has a doctorate of medicine from New York University School of Medicine. Dr. Byrne went on to complete a psychiatry residency at Mt. Sinai School of Medicine in New York. In addition to her work as a psychiatrist, Dr. Byrne has performed extensive research on attention, memory, and depression. As a board-certified adult psychiatrist, Dr. Byrne focuses on the needs of each patient to pro

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