2016 TMS Update at CPCH

As you may recall, in 2016 CPCH has been treating patients with Major Depressive Disorder with TMS (transcranial magnetic stimulation). As part of the Gil Internship, we were fortunate to have Swapnil Patel, a UNC undergraduate Psychology major, to help us analyze our TMS outcomes data for 13 patients who completed the TMS protocol at CPCH. We wanted to share these exciting results:

 

Patient Demographics (what kind of patients completed the TMS protocol)

Patient Demographics

Measurement Tool – PHQ-9

THE PATIENT HEALTH QUESTIONNAIRE (PHQ-9) OVERVIEW

The PHQ-9 is a multipurpose instrument for screening, diagnosing, monitoring and measuring the severity of depression:
• The PHQ-9 incorporates DSM-IV depression diagnostic criteria with other leading major depressive symptoms into a brief self-report tool.
• The tool rates the frequency of the symptoms, which factors into the scoring severity index.
• Question 9 on the PHQ-9 screens for the presence and duration of suicide ideation.
• A follow up, non-scored question on the PHQ-9 screens and assigns weight to the degree to which depressive problems have affected the patient’s level of function.

Response = 50% reduction of symptoms on the PHQ-9
Remission = PHQ-9 score < 5

OVERALL RESULTS

Figure 1a. Average patient PHQ-9 scores at baseline and following TMS treatment (n=13)

PHQ9 Scores

Figure 1b. Average patient response and remission rates through 20 TMS sessions (n=13)

Percentage of Patients

RESULTS FROM PATIENTS WITH SEVERE DEPRESSION

Figure 2a. Patient PHQ-9 scores after 10 and 20 TMS sessions with baseline PHQ-9 ≥ 20 (n=5)

PHQ-9 Scores

RESULTS FROM PATIENTS WITH MODERATE DEPRESSION

Figure 3a. Patient PHQ-9 scores after 10 and 20 TMS sessions with baseline PHQ-9 11-19 (n=7)

PHQ-9 Scores1

RESULTS FROM PATIENTS WITH MILD DEPRESSION

Figure 4a. Patient PHQ-9 scores after 10 and 20 TMS sessions with baseline PHQ-9 ≤ 10 (n=1)

PHQ-9 Scores after 10 sessions

So what does it all mean? Here are the take-away points:

Some additional notes on the TMS experience:

If you would like to know if you are a candidate for dTMS please contact our offices at 919-636-5240.

Live Mentally Healthy,
Dr. Jennie Byrne

Author
Dr. Jennie Byrne, M.D., PhD.

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