4 New Antidepressants

4 New Antidepressants

If you or a loved one suffer from depression, there are some new medications for depression that you should be aware of.

Vilazodone (Viibryd)

  • approved by FDA in 2011
  • sometimes called a “SPARI” which stands for “serotonin partial agonist/reuptake inhibitor”
  • may show response within 1-2 weeks, but generally need 6 weeks for remission
  • no clear evidence to show decreased sexual side effect rate
  • may be more effective for depressed patients who also have anxiety

Levomilnacipran (Fetzima)

  • approved by FDA in 2013
  • is an “SNRI” which stands for “serotonin and norepinephrine reuptake inhibitor – more selective for norepineephrine

Vortioxetine (Trintellix)

  • approved by FDA in 2013
  • sometimes called “multimodal agent” because acts as serotonin selective reuptake inhibitor, agonist of 5HT-1A receptors,
  • partial agonist at 5-HT1B receptors, antagonist at 5-HT3 and 5-HT7 receptors
  • has shown some improvement on cognitive testing, but has not been FDA approved for cognitive dysfunction in Major Depressive Disorder


  • not FDA approved for depression, but is approved as preoperative general anesthesia
  • is an antagonist of the NMDA receptor, does not work on serotonin or norepinephrine
  • can be given intravenously, or compounded to oral, sublingual, intranasal forms
  • use is considered experimental at this time
  • may be helpful for rapid but short-lived relief of depression

I hope this information is helpful. If you think you or a loved one is suffering from depression, we are here to help! Please call us at 919-636-5240 for a consultation.

Live Mentally Healthy,
Dr. Jennie Byrne

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